Safer Cancer Drug Dosing Ahead
Safer Cancer Drug Dosing: ASCO and FDA Push for Optimal, Not Maximum, Doses
Concerns are growing that cancer drugs may be given at higher doses than patients actually need, leading to unnecessary side effects and treatment interruptions. The American Society of Clinical Oncology (ASCO), working with the FDA, has issued new principles urging a shift from the old “maximum tolerated dose” approach toward finding the “optimal effective dose.” This matters for newer treatments like immunotherapies and targeted therapies, where higher doses don’t always improve results but often increase harmful side effects. Patient surveys show many people with advanced cancers struggle with severe treatment side effects, and oncologists frequently lower doses early on to help patients stay on therapy.
To fix this, ASCO recommends designing trials that test multiple dosage levels, tailoring studies to real-world patients, and improving how patient-reported side effects are tracked. These steps align with the FDA’s Project Optimus, which is pushing for better drug dosing in cancer research. For patients, this shift offers hope for treatment that works just as well—or better—while being easier to tolerate, helping people with advanced cancer focus on living fully instead of fighting side effects. (Source: Oncology News Central)
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New Clues on How Cancer Spreads
New Clues on Cancer Metastasis: How “Shape-Shifting” Cells Spread and Survive
For decades, doctors have known that cancer’s deadliest threat comes not from the original tumor but from metastasis — when cancer spreads to other parts of the body. Up to 90% of cancer deaths are linked to this process. Now, researchers led by Dr. Joan Massagué at Memorial Sloan Kettering are uncovering important insights into how metastatic cells survive, hide, and return to grow new tumors years later. These “shape-shifting” cells act like stem cells, traveling back in time to earlier, more flexible states that allow them to adapt and resist treatment. They can also slip into dormancy, hiding from the immune system until the conditions are right to awaken and spread again.
Scientists are learning that metastatic cells use different strategies depending on the type of cancer and the organ they invade. They can even change their physical shape to avoid being destroyed by the immune system. These discoveries open new possibilities for treatment — from targeting the hidden “time traveler” state, to waking dormant cells so the immune system can attack them, to blocking proteins that allow cancer cells to evade detection. While challenges remain, Dr. Massagué emphasizes that metastasis is no longer an automatic death sentence. With advances in immunotherapy and targeted research, controlling — and in some cases curing — stage 4 cancer is becoming more possible than ever before. (Source: Memorial Sloan Kettering)
Future of Cancer Screening Shows Hope
Future of Cancer Screening: Multi-Cancer Early Detection Brings New Hope
Most cancers are still found late because only five types—colon, cervical, breast, lung, and prostate—have routine screening. A new direction called multi-cancer early detection (MCED) aims to spot cancers with a single test. Instead of hunting for tiny, hard-to-find tumor DNA fragments in the blood, researchers are building tiny “sensors” that circulate in the body and switch on when they meet enzymes made by early cancer cells. These sensors release a synthetic marker that shows up clearly in samples like urine, creating a much stronger, earlier signal than traditional tests in preclinical studies.
Why it matters: this approach could make screening simpler, more accurate, and more accessible—potentially even via low-cost strips for clinics with limited resources—and may help catch hard-to-find cancers (including lung cancer) sooner, when treatment works best. Logic-based sensor designs (think an “AND” gate requiring multiple cancer signals) may reduce false alarms, and early clinical use could include tracking treatment response or watching for recurrence. Safety testing is still ahead, but progress is rapid. If successful, MCED could shift many diagnoses from late-stage to early-stage—and offer hope and options for people living with or at risk for advanced disease. (Source: MIT Technology Review)
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Yoga, Meditation, and More Bring Relief
Yoga, Meditation, and Integrative Medicine Ease Cancer Treatment Side Effects
A new clinical trial shows that live, online classes in yoga, meditation, tai chi, and fitness can do more than just help patients feel calmer — they can actually reduce the side effects of cancer treatment. Patients who joined these virtual integrative medicine sessions during chemotherapy, radiation, immunotherapy, or targeted therapy reported less fatigue, anxiety, depression, and trouble sleeping. Remarkably, they also needed fewer hospital stays, and when they were admitted, their time in the hospital was much shorter.
This approach, offered through Memorial Sloan Kettering’s Integrative Medicine at Home program, costs $25 per month and is available to patients anywhere — not just those treated at MSK. Many patients find the classes give them both physical strength and emotional support by connecting with others going through cancer. Other services like acupuncture and music therapy can also play a role in making treatment more tolerable. Research continues to grow, with hopes of expanding access nationwide. For patients and caregivers, these integrative therapies provide a safe, evidence-based way to feel stronger and more supported throughout cancer treatment. (Source: Memorial Sloan Kettering)
Second Opinions Can Save Lives
Why Getting a Second Opinion for Cancer Can Save Your Life
Being told you have cancer is overwhelming, and it’s easy to feel pressured to start treatment right away. But getting a second opinion can make a huge difference—it may confirm the diagnosis, catch mistakes, or suggest new treatment options. For patients with stage 4 or hard-to-treat lung cancer, this extra step can open the door to advanced therapies and clinical trials not available everywhere.
Specialists at National Cancer Institute-designated centers look deeper than a single test. They review scans, biopsy slides, and genetic testing to match you with the best targeted therapy or immunotherapy. Many doctors welcome second opinions, and sometimes both teams can work together—giving you more support, not less.
Most importantly, a second opinion can give you peace of mind. Knowing your diagnosis and plan have been double-checked helps you move forward with confidence and focus on what matters most: your care and your life. (Source: Winship Magazine)
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What’s Driving Lung Cancer in Nonsmokers?
What’s Driving Lung Cancer in Nonsmokers? Understanding RET-Positive Lung Cancer
Lung cancer isn’t just a smoker’s disease. In fact, up to 20% of lung cancer patients have never smoked, and many are younger women. One reason? Genetic mutations like RET fusions, which can drive cancer growth even without traditional risk factors. This type, called RET-positive lung cancer, is more common in never smokers and doesn’t show up on routine screenings.
That’s why genetic testing (also called biomarker testing) is critical. It can help doctors choose targeted treatments that work better and offer more hope—especially for patients with stage 4 or hard-to-treat lung cancer. Even if you’ve never smoked, if you’re experiencing unusual symptoms or have lung cancer in your family, talk to your doctor about testing. Early detection and personalized care are changing what’s possible. (Source: American Cancer Society, Yale Medicine, J Clin Oncol)
Living Well with Stage 4 Cancer: Stories of Hope
A stage 4 cancer diagnosis, where cancer has spread beyond the original site, can be frightening. But thanks to advances in treatments and supportive care, many people are living longer and maintaining a good quality of life. At Memorial Sloan Kettering, patients like LaDawn Jefferson, Dennis Flaherty, and Antonio Lekhrajmal have beaten the odds—returning to activities they love, from running marathons to creating art while managing their disease with personalized care.
Others, like Jacqueline Hickey, have found relief from symptoms such as pain through coordinated treatments that address metastatic cancer’s challenges. These stories show that with the right care and new therapies, people with advanced cancer can continue to live fully and find hope even in difficult times. (Source: Memorial Sloan Kettering)
Hope from Metastasis Research
Metastasis is when cancer spreads from the original tumor to other parts of the body, and it’s often the toughest part to treat. Researchers at Memorial Sloan Kettering are studying how these metastatic cancer cells change and adapt to survive treatments. They found that metastatic cells can “shift” their identity to better survive, which helps explain why they become harder to stop over time.
At MSK, doctors are creating patient-based 3D models to better understand lung cancer spread and to test how different treatments work. There’s also a clinical trial exploring a drug that stops cancer cells in the brain and spine from stealing iron, which they need to grow and to avoid immune attack. This research is paving the way toward treatments that are more targeted and personalized.
For patients with late-stage or metastatic cancer, these advances offer hope for longer control of the disease and, one day, new ways to stop metastasis altogether. (Source: Memorial Sloan Kettering)
Precision Cancer Testing Brings New Hope
At Memorial Sloan Kettering’s Center for Molecular Oncology, doctors use advanced testing to find the exact changes in a person’s cancer cells. This helps them choose treatments that specifically target those changes, giving patients a better chance at controlling their cancer. Over the past decade, tests like MSK-IMPACT® have made it possible to check for hundreds of genetic changes, even through simple blood tests, helping people with advanced or rare cancers find personalized therapies. But DNA testing doesn’t show everything, so new tests that look at how cancer cells use genes (called RNA tests) and even check all of a person’s genes (whole-genome sequencing) are coming soon. These tools aim to help patients who don’t respond to current treatments and could also guide immunotherapy, which uses the body’s immune system to fight cancer.
This kind of testing can also find inherited gene changes that increase cancer risk, helping families take steps to prevent cancer early. One inspiring example is patient Michael Wolff, a jazz pianist whose rare cancer was identified through molecular testing. Doctors found a gene mutation that led to a drug treatment which quickly stopped his symptoms and shrank his tumors. His success shows how precise testing can save lives and open the door to new treatments for cancers that were once very hard to treat. For patients with stage 4 or difficult cancers, these advances mean more hope for better, tailored care—and the chance for improved quality of life. (Source: Memorial Sloan Kettering)
Cancer Vaccines Offer New Hope
Cancer vaccines, once considered a distant dream, are becoming a hopeful reality thanks to groundbreaking research inspired by the success of COVID-19 mRNA vaccines. Unlike traditional vaccines designed to prevent illnesses, therapeutic cancer vaccines teach the body’s own immune system how to recognize and attack cancer cells. Memorial Sloan Kettering (MSK) researchers, building on ideas first imagined over a century ago, have significantly advanced these vaccines. Dr. David Scheinberg, a leading researcher at MSK, explains that new technologies now allow vaccines to target multiple proteins specific to cancer cells, making treatments more effective and reducing side effects compared to chemotherapy and radiation.
One promising area is personalized mRNA cancer vaccines, custom-made for each patient based on their tumor’s unique characteristics. Early trials, particularly in pancreatic cancer, have shown encouraging results, with vaccinated patients’ immune cells remaining active for years. Additionally, MSK researchers are developing off-the-shelf vaccines targeting common cancer markers, such as WT1, found in leukemia and ovarian cancer. These vaccines could soon offer accessible, affordable options for many patients. The rapid progress in cancer vaccine development at MSK offers genuine optimism, especially for patients fighting advanced or hard-to-treat cancers. (Source: Memorial Sloan Kettering)
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When a Cough Could Be Lung Cancer
A chronic cough is often just a sign of something like a cold, allergies, or asthma — but in some cases, it may be a warning sign of lung cancer. According to lung cancer experts, including Dr. Fatemeh Ardeshir-Larijani of Emory University, a cough that lasts longer than 8 to 12 weeks, worsens over time, or comes with other symptoms like coughing up blood, chest tightness, or unexplained weight loss should not be ignored. While many types of cough can happen with lung cancer, the most common is a dry, persistent cough that doesn’t go away with typical treatments.
People with lung cancer may also experience pressure in the chest, shortness of breath, or coughing due to fluid buildup around the lungs. Treatments to ease this kind of cough vary. For some, shrinking the tumor with chemotherapy, immunotherapy, or targeted therapy helps reduce coughing. Others may need fluid drained from their lungs or use home remedies like steam, hydration, or honey to manage the symptom. While only a small number of people with a chronic cough actually have lung cancer, it’s especially important for those at high risk — such as longtime smokers — to speak with their doctor and consider annual lung cancer screenings. (Source: Verywell Health)
Consider Donating to Advance Research
RET-positive lung cancer is a rare type of cancer driven by a change in a gene called RET, which stands for “rearranged during transfection.” This gene helps control how cells grow and divide. When it fuses with another gene or mutates, it can cause cancer to grow and spread—especially in certain lung and thyroid cancers. Because RET changes are so rare, researchers don’t have enough lab models—called cancer cell lines—to fully study how the cancer behaves or how it becomes resistant to treatment.
One powerful way patients can help is by donating tumor tissue during a biopsy or surgery. That tissue can be used to grow RET-positive cancer cells in the lab, giving scientists tools to test new treatments and develop better, more personalized options. Thanks to the generosity of several RET patients, four new cancer cell lines are now being developed. If you’re a patient, talk to your care team about donating—your gift could move research forward and bring better treatments to others living with RET-driven cancer. (Source: The Happy Lungs Project)
