Hope from Metastasis Research
Hope from Metastasis Research: New Advances for Stage 4 Cancer
Learn how metastasis research is uncovering how cancer spreads and resists treatment, including 3D patient models and new clinical trials offering hope for stage 4 cancer.
Metastasis is when cancer spreads from the original tumor to other parts of the body, and it’s often the toughest part to treat. Researchers at Memorial Sloan Kettering are studying how these metastatic cancer cells change and adapt to survive treatments. They found that metastatic cells can “shift” their identity to better survive, which helps explain why they become harder to stop over time.
At MSK, doctors are creating patient-based 3D models to better understand lung cancer spread and to test how different treatments work. There’s also a clinical trial exploring a drug that stops cancer cells in the brain and spine from stealing iron, which they need to grow and to avoid immune attack. This research is paving the way toward treatments that are more targeted and personalized.
For patients with late-stage or metastatic cancer, these advances offer hope for longer control of the disease and, one day, new ways to stop metastasis altogether. (Source: Memorial Sloan Kettering)
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Resources for Living With Stage 4 Cancer
Learn more about topics like metastasis research, along with other important aspects of living with Stage 4 cancer. Become a member of our community to gain access to trusted resources, as well as online support and education from Dr. Sharon May, Ph.D., LMFT.
Precision Cancer Testing Brings New Hope
Precision Cancer Testing Brings New Hope for Stage 4 Cancer
At Memorial Sloan Kettering’s Center for Molecular Oncology, doctors use advanced testing to find the exact changes in a person’s cancer cells. This helps them choose treatments that specifically target those changes, giving patients a better chance at controlling their cancer. Over the past decade, tests like MSK-IMPACT® have made it possible to check for hundreds of genetic changes, even through simple blood tests, helping people with advanced or rare cancers find personalized therapies. But DNA testing doesn’t show everything, so new tests that look at how cancer cells use genes (called RNA tests) and even check all of a person’s genes (whole-genome sequencing) are coming soon. These tools aim to help patients who don’t respond to current treatments and could also guide immunotherapy, which uses the body’s immune system to fight cancer.
This kind of testing can also find inherited gene changes that increase cancer risk, helping families take steps to prevent cancer early. One inspiring example is patient Michael Wolff, a jazz pianist whose rare cancer was identified through molecular testing. Doctors found a gene mutation that led to a drug treatment which quickly stopped his symptoms and shrank his tumors. His success shows how precise testing can save lives and open the door to new treatments for cancers that were once very hard to treat. For patients with stage 4 or difficult cancers, these advances mean more hope for better, tailored care—and the chance for improved quality of life. (Source: Memorial Sloan Kettering)
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Cancer Vaccines Offer New Hope
Cancer Vaccines Offer New Hope: mRNA Breakthroughs for Stage 4 Cancer
Discover how therapeutic and personalized mRNA cancer vaccines are training the immune system to fight advanced cancers, with promising early clinical trial results.
Cancer vaccines, once considered a distant dream, are becoming a hopeful reality thanks to groundbreaking research inspired by the success of COVID-19 mRNA vaccines. Unlike traditional vaccines designed to prevent illnesses, therapeutic cancer vaccines teach the body’s own immune system how to recognize and attack cancer cells. Memorial Sloan Kettering (MSK) researchers, building on ideas first imagined over a century ago, have significantly advanced these vaccines. Dr. David Scheinberg, a leading researcher at MSK, explains that new technologies now allow vaccines to target multiple proteins specific to cancer cells, making treatments more effective and reducing side effects compared to chemotherapy and radiation.
One promising area is personalized mRNA cancer vaccines, custom-made for each patient based on their tumor’s unique characteristics. Early trials, particularly in pancreatic cancer, have shown encouraging results, with vaccinated patients’ immune cells remaining active for years. Additionally, MSK researchers are developing off-the-shelf vaccines targeting common cancer markers, such as WT1, found in leukemia and ovarian cancer. These vaccines could soon offer accessible, affordable options for many patients. The rapid progress in cancer vaccine development at MSK offers genuine optimism, especially for patients fighting advanced or hard-to-treat cancers. (Source: Memorial Sloan Kettering)
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Young Mom Beats Lung Cancer Odds
Young Mom Beats Lung Cancer Odds: Lauren’s Survivor Story
Just as 38-year-old Lauren was getting back into shape after becoming a new mom, her life changed overnight. A nagging pain in her neck led to scans that uncovered a mass in her lung—stage 3 lung cancer. She went from running miles to navigating CT scans and the shock of a diagnosis she never imagined. “I remember saying, ‘Am I going to make it to my daughter Elle’s second birthday?’” Lauren recalled.
Motivated by her young daughter, Lauren faced treatment head-on. She preserved her fertility, then began chemotherapy and radiation to shrink the tumors. A portion of her lung was surgically removed after a month of healing. Throughout it all, she clung to her purpose: “Elle gave me the motivation to get up and get infusions when I was feeling my worst.” Genetic testing revealed an EGFR mutation—common in nonsmokers like Lauren and a key to unlocking targeted therapy. Now, with no evidence of disease, Lauren stays vigilant with regular scans and remains a voice of hope.
“Your support literally saves lives,” she says, grateful for both friends and strangers who make research breakthroughs possible. (Source: GO2 for Lung Cancer)
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When a Cough Could Be Lung Cancer
When a Cough Could Be Lung Cancer: Signs, Risks, and Next Steps
A chronic cough is often just a sign of something like a cold, allergies, or asthma — but in some cases, it may be a warning sign of lung cancer. According to lung cancer experts, including Dr. Fatemeh Ardeshir-Larijani of Emory University, a cough that lasts longer than 8 to 12 weeks, worsens over time, or comes with other symptoms like coughing up blood, chest tightness, or unexplained weight loss should not be ignored. While many types of cough can happen with lung cancer, the most common is a dry, persistent cough that doesn’t go away with typical treatments.
People with lung cancer may also experience pressure in the chest, shortness of breath, or coughing due to fluid buildup around the lungs. Treatments to ease this kind of cough vary. For some, shrinking the tumor with chemotherapy, immunotherapy, or targeted therapy helps reduce coughing. Others may need fluid drained from their lungs or use home remedies like steam, hydration, or honey to manage the symptom. While only a small number of people with a chronic cough actually have lung cancer, it’s especially important for those at high risk — such as longtime smokers — to speak with their doctor and consider annual lung cancer screenings. (Source: Verywell Health)
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Not Done Living
Stage 4 HER2-Positive Lung Cancer: Gary’s Story on Enhertu
When Gary W. was diagnosed with stage 4 lung cancer, his life took a sharp turn—but he never let it stop him. Married for 44 years and retired at age 59, Gary was on a dream trip with his wife visiting U.S. National Parks when a lingering cough led to a life-changing diagnosis. Doctors found tumors in both lungs and confirmed a HER2-positive mutation. Today, he is thriving on Enhertu, a drug originally designed for breast cancer, and credits his stable health, his family, and his mindset for helping him stay active and optimistic. He walks daily, handles chores, travels, and says, “I live very much like a normal person.”
Gary’s story is a powerful reminder that lung cancer is not a dead end. With better treatments and more research happening every year, there is real hope for patients—even with stage 4 disease. His advice to others: don’t give up, stay informed, and know that there are more options than ever before. “I don’t ever want to stop living,” he says. “I was determined not to let lung cancer slow me down—if anything, it’s accelerated me.”
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Consider Donating to Advance Research
RET-Positive Lung Cancer Research: How Tissue Donation Helps
RET-positive lung cancer is rare, and researchers need better lab models to study it. Learn how donating tumor tissue can help create cell lines and advance targeted treatments.
RET-positive lung cancer is a rare type of cancer driven by a change in a gene called RET, which stands for “rearranged during transfection.” This gene helps control how cells grow and divide. When it fuses with another gene or mutates, it can cause cancer to grow and spread, especially in certain lung and thyroid cancers. Because RET changes are so rare, researchers don’t have enough lab models called cancer cell lines. That makes it harder to study how the cancer behaves and becomes resistant to treatment.
One powerful way patients can help is by donating tumor tissue during a biopsy or surgery. That tissue can be used to grow RET-positive cancer cells in the lab, giving scientists tools to test new treatments and develop better, more personalized options. Thanks to the generosity of several RET patients, four new cancer cell lines are now being developed. If you’re a patient, talk to your care team about donating. Your gift could move research forward and help bring better treatments to others living with RET-driven cancer. (Source: The Happy Lungs Project)
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Targeted Therapies Bring New Hope in Lung Cancer
New Lung Cancer Treatments Offering Hope Through Research
Recent advancements in lung cancer treatment are offering new hope, especially for those with advanced or hard-to-treat cases. Scientists are developing highly targeted drugs that focus on the unique features of each person’s cancer. These treatments aim to attack only the cancer cells—sparing healthy ones—and may reduce side effects while helping patients live longer. New tools like antibody-drug conjugates (ADCs) and bispecific antibodies are leading the way, with some early results showing success even in cases where standard chemo and immunotherapy haven’t worked well.
Some of these new drugs target specific proteins found in certain lung cancers, including those seen in both non-small cell (NSCLC) and small cell lung cancer (SCLC). Researchers are also exploring ways to combine immune-based therapies with these new targeted drugs to overcome resistance and keep the cancer from returning. While many of these treatments are still in early testing, they represent a major step toward more personalized—and more hopeful—options for lung cancer patients. (Source: Drug Target Review)
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Study Offers Hope for Women with Lung Cancer
Lung Cancer Treatment for Women: New Research Insights
A new study is exploring why some treatments don’t work as well for women with squamous cell lung cancer, a common type of non-small cell lung cancer often linked to smoking. This form of lung cancer hasn’t responded well to the newer targeted therapies that help other types of lung cancer. But researcher Dr. Milica Momcilovic is working to change that by studying how hormones like estrogen may affect treatment outcomes in women.
What is TAK228, and why is it being studied?
TAK228 (also called sapanisertib) is an investigational targeted therapy designed to block the mTOR pathway, a major growth-and-survival signaling system that many cancers rely on. It’s considered a dual mTORC1/mTORC2 inhibitor, meaning it can shut down two key “switches” within the mTOR system that help tumor cells grow and resist treatment. Researchers are studying TAK228 in lung cancer, especially squamous cell lung cancer. This subtype has fewer targeted treatment options than other forms of non-small cell lung cancer.
Her early research in lab and animal models suggests that TAK228 may affect male and female tumors differently. In mouse models of squamous cell lung cancer, TAK228 reduced tumor growth more in male mice than in female mice. Researchers think estrogen-related signaling may interfere with how female tumors respond. When researchers paired TAK228 with an anti-estrogen medication (such as letrozole, a drug used to lower estrogen levels), tumors in female mice responded better and tumor growth decreased more significantly. This could eventually lead to more personalized treatments for women with lung cancer, helping doctors choose the right therapies and improving survival and quality of life. (Source: American Lung Association)
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New Lung Cancer Treatments Show Real Promise
New 2025 Research Brings Hope for Advanced Lung Cancer
New research shared in 2025 brings hope for people with advanced non-small cell lung cancer. Scientists presented several treatment updates that are helping patients live longer with fewer side effects. One medicine, aumolertinib, helped slow cancer growth—especially when combined with chemotherapy. Aumolertinib is a targeted therapy that blocks the EGFR protein, which drives tumor growth in certain lung cancers. When added to chemotherapy, it has been shown to significantly delay cancer progression and is generally well tolerated. Another drug, JYP0322, worked well for people with a rare type of lung cancer, even when the cancer had spread to the brain. JYP0322 is an investigational ROS1 inhibitor designed to cross the blood-brain barrier, making it effective against brain metastases. Early trials showed promising responses in patients who had previously received other ROS1-targeted treatments.
Other promising treatments are helping people whose cancer carries uncommon genetic changes. A pill called zongertinib helped many patients and caused fewer side effects than older drugs. Zongertinib targets HER2-mutated lung cancer, which is rare but often aggressive. Clinical studies showed it shrinks tumors effectively and causes fewer side effects compared with older treatments. Another new medicine, zoldonrasib, showed early success in shrinking tumors in patients whose cancer had stopped responding to other treatments. While one immune-based drug didn’t work as well as hoped, researchers believe it still has potential. Zoldonrasib, is designed for cancers with the KRAS G12D mutation, a mutation that was historically difficult to treat. Early trial results indicate it can shrink tumors in patients whose cancer no longer responds to standard therapies. Overall, the message is clear: more personalized and effective treatments are on the horizon. (Source: American Association for Cancer Research)
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Gene Therapy Gives Stage 4 Mom More Time
Sara Whitlock: Thriving After Stage 4 Lung Cancer Diagnosis
Sara Whitlock was diagnosed with stage 4 lung cancer in 2010 at just 47. She feared she wouldn’t live to see her daughters grow up. Her outlook was bleak—only a 3% chance of surviving five years. Yet more than a decade later, Sara is thriving, watching her daughters graduate and enjoying everyday life with her husband. Her journey began with traditional chemotherapy and radiation. A major turning point came in 2017 when she joined a clinical trial for a gene-targeted therapy called selpercatinib (LOXO-292). The drug is designed for patients with a rare mutation called RET fusion-positive non-small cell lung cancer, found in only about 2% of lung cancer patients.
Sara’s story is a powerful example of how targeted therapies, drugs developed to block specific cancer-driving mutations, are transforming treatment and survival for people with advanced lung cancer. Unlike the harsh side effects of earlier treatments, this pill-based therapy has been easier to tolerate, and Sara currently has no signs of cancer. While she remains aware that her cancer could return, she’s living fully and cherishing every moment. Her story is a reminder that even with a stage 4 diagnosis, new research and personalized treatments are rewriting the possibilities for patients—and their families. (Source: Cleveland Clinic)
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26 Years Living With Stage 4 Lung Cancer
Wells Stage 4 Lung Cancer Survivor Story
When Wells W. was diagnosed with stage 4 lung cancer in 1998, doctors told him he had just 10 months to live. But Wells, a scientist by training, took charge of his care—researching treatments, getting second opinions, and joining a compassionate use trial for Iressa (gefitinib), a targeted therapy that matched his EGFR mutation. His tumors shrank enough for surgery, and he’s continued to live cancer-managed ever since.
Now 91, Wells has dedicated his life to lung cancer advocacy, co-founding GO2 for Lung Cancer and mentoring others facing the disease. His journey proves that even with a stage 4 diagnosis, hope, action, and long-term survival are possible. (Source: GO2 for Lung Cancer)
Caroline’s Story: Facing Lung Cancer with Family and Hope
Caroline’s EGFR Lung Cancer Genetic Mutation Story
Caroline, a nurse practitioner from Louisiana, knows the impact of lung cancer firsthand due to her family’s experience. Several relatives who never smoked developed lung cancer, prompting genetic testing that revealed an EGFR gene mutation affecting Caroline, her mother, and grandmother. Shortly after having her baby, Caroline’s own lung screening showed nodules, leading to surgery and challenging complications that required multiple hospitalizations. She eventually found a supportive medical team closer to home at MD Anderson, where she continues to receive regular screenings.
Embracing a positive outlook, Caroline draws strength from her family and friends and actively raises awareness about genetic mutations in lung cancer, inspired by her meeting with Dr. Geoff Oxnard, hoping her experience will encourage and inform others. (Source: EGFR Resisters)
Targeted Pill Delays Lung Cancer Return
Tagrisso (Osimertinib) Delays EGFR Lung Cancer Recurrence
A new treatment is bringing hope to people with stage 3 non-small cell lung cancer (NSCLC) that has a mutation in a gene called EGFR, which stands for epidermal growth factor receptor. This gene helps cells grow, and when it’s mutated, it can cause cancer to grow faster. These EGFR mutations are found in many people with lung cancer—especially never smokers and those of Asian descent.
In the LAURA trial, patients who had already completed chemotherapy and radiation were given the pill Tagrisso (osimertinib) to help prevent their cancer from coming back. The study, led by Dr. Suresh Ramalingam of Winship Cancer Institute at Emory University, showed powerful results: people who took Tagrisso stayed cancer-free for a median of 39 months—compared to just 5.6 months in the group that didn’t take the drug. That means Tagrisso reduced the risk of cancer returning or spreading by 84%.
Tagrisso (osimertinib) is a once-daily targeted therapy used to treat EGFR-mutated non-small cell lung cancer. It works by blocking the abnormal EGFR signals that cause cancer cells to grow, helping delay recurrence and slow disease progression. Tagrisso has become a standard treatment in several stages of EGFR-positive lung cancer and is especially valued for its ability to help protect against cancer spreading to the brain.
While some patients experienced side effects like inflammation in the lungs, no new safety issues were found. Tagrisso is now the first targeted therapy to show such a strong benefit for stage 3 EGFR-positive lung cancer. Doctors believe this could become the new standard of care—offering more time and hope to patients with this aggressive form of lung cancer. (Source: Winship Cancer Institute at Emory University)
New Targets Found in Rare Cancers
Researchers Identify New Treatment Targets for Hard-to-Treat Cancers
Researchers have discovered four new possible treatment targets for hard-to-treat cancers like osteosarcoma (a bone cancer), glioblastoma (a fast-growing brain tumor), and rare pancreatic tumors. These cancers often survive by using a backup system to protect their DNA called the ALT pathway (short for Alternative Lengthening of Telomeres). This system helps cancer cells keep dividing and growing, even when most treatments stop working.
To find these weak spots, scientists developed a new tool called BLOCK-ID, which acts like a microscope for cancer’s stress points. When cancer cells try to copy their DNA and make new cells, things can go wrong—this is called replication stress. BLOCK-ID lets researchers see which proteins rush in to help the cancer survive during this stress. One of the newly discovered proteins, TRIM24, along with three others, may be helping these tough cancers grow. Blocking them could shut down the cancer’s defenses.
More research is underway to test whether these new targets can lead to real treatments. For patients with aggressive or rare cancers, this offers new hope for future therapies that go after cancer at its core. (Source: Winship Cancer Institute at Emory University)
Coping with Cancer: Finding Strength, Hope, and Meaning
Emotional Support & Resilience
Receiving a cancer diagnosis is life-changing. It can feel like the ground beneath you has shifted, leaving you overwhelmed, afraid, and uncertain about the future. Whether you’re newly diagnosed, undergoing treatment, or navigating life after treatment, coping with cancer is a deeply personal and ongoing journey.
While no two experiences are the same, there are universal strategies and tools that can help you regain a sense of control, hope, and emotional resilience. This guide offers supportive, actionable steps to help you cope with cancer in a way that honors your emotions, your body, and your story.
1. Acknowledge and Accept Your Emotions
One of the first steps in coping with cancer is acknowledging your emotional response. Fear, anger, sadness, confusion, and even guilt are all common reactions. These emotions can come in waves or appear without warning. It’s okay to feel overwhelmed—there is no “right” way to respond.
Try this:
● Keep a journal to explore your thoughts and name your emotions.
● Speak kindly to yourself. Say, “I’m feeling afraid right now,” rather than “I shouldn’t feel this way.”
● Practice gentle affirmations: “It’s okay to feel what I feel. I am doing my best.”
Recognizing your emotional landscape helps you move through it with more compassion and less shame.
2. Build a Support System That Works for You
Coping with cancer is not something you have to do alone. Let people help you in ways that feel safe and meaningful. Support can take different forms for everyone—some need practical help, others require a quiet presence, and some need professional guidance.
Support ideas:
● Join an in-person or virtual cancer support group.
● Choose one trusted person to relay medical updates to others.
● Work with a therapist who specializes in chronic illness or grief.
Having a support system in place can reduce feelings of isolation and remind you that you are not alone.
3. Focus on What You Can Control
Cancer can leave you feeling powerless. While you may not have control over your diagnosis or treatment plan, you can make choices about how you manage each day. Shifting focus to what’s within your control can restore a sense of agency.
You might choose to:
● Decide who you share your diagnosis with and when.
● Set limits with people who increase stress or make unhelpful comments.
● Maintain small routines that nourish you, like eating well, resting, or taking a gentle walk.
Small decisions can make a big difference in how you experience each day.
4. Take Care of Your Whole Self
Coping with cancer goes beyond the physical—it also involves caring for your emotional, mental, and spiritual self. Whether you lean into creativity, spirituality, or stillness, give yourself permission to care for your whole being.
Ideas to explore:
● Practice meditation, deep breathing, or gentle yoga.
● Express yourself through painting, journaling, or music.
● Spend time in nature or with animals, if that soothes you.
● Reflect on or engage in your spiritual or religious practices.
Self-care doesn’t have to be elaborate. It’s about honoring what helps you feel most like you.
5. Make Space for Joy and Meaning
Yes, even amid cancer, moments of joy, beauty, and meaning can still emerge. These moments don’t erase the pain—they coexist with it, offering light in the dark.
Notice or create:
● Simple joys like a warm cup of tea, sunlight on your skin, or a favorite show.
● Creative projects, such as writing letters, scrapbooking, or making art.
● Opportunities to reflect on your values and what matters most to you. Finding meaning can be part of the healing process—not because everything happens for a reason, but because you can create your own purpose through connection, creativity, and presence.
6. Ask for and Accept Help—Without Guilt
Many people find it challenging to ask for help, especially when they’re accustomed to being independent or caregivers themselves. But part of coping with cancer is learning to receive support without guilt. People want to help. Let them.
Try saying:
● “Yes, that would be really helpful, thank you.”
● “I’m not sure what I need, but I appreciate you being here.”
● “I need to rest right now—can we talk later?”
Letting others in isn’t a burden; it’s a bridge to deeper connection and relief.
7. Seek Professional Support That Resonates with You
You don’t need to be in crisis to benefit from therapy. In fact, many people find therapy to be one of their most powerful tools for coping with cancer. Whether you’re processing grief, facing fear, or navigating identity changes, having a professional to walk beside you can offer clarity and comfort.
Therapeutic options include:
● Cognitive Behavioral Therapy (CBT): For managing anxiety and negative thought patterns.
● Acceptance and Commitment Therapy (ACT): To help you accept what’s out of your control while committing to actions that align with your values.
● EMDR Therapy: Especially helpful if the trauma of diagnosis or treatment lingers.
● Supportive Counseling: A safe space to talk openly and receive compassion.
Many therapists specialize in working with people experiencing medical trauma, chronic illness, or grief—look for someone who gets it.
Final Thoughts: You Are Not Alone
Coping with cancer is hard, and there’s no perfect roadmap. Some days will feel okay. Others may find it unbearable. But you don’t have to go through it alone, and you don’t have to do it all at once.
You are allowed to feel your feelings, ask for help, take breaks, laugh, cry, and everything in between. You are still you—whole and worthy—no matter what this diagnosis tries to take away.
Healing isn’t linear, and progress can be messy. But there is strength in vulnerability, hope in connection, and resilience in simply continuing forward.
If you or someone you love is coping with cancer, reach out for support, for care, for someone to walk with you. You are doing incredibly brave things—one day, one moment, one breath at a time.
Need someone to talk to?
Whether you’re in active treatment or recovery, therapy can provide a stable foundation for processing your journey. Reach out today—we’re here for you. Towler Counseling LLC: www.towler-counseling.com
Author- Tara Towler Cumby LPC CPCS CMAC
